The Helmholtz Sino-German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, 710038 Xi'an, Shaanxi Province, PR China.
BMC Cancer. 2011 Mar 28;11:111. doi: 10.1186/1471-2407-11-111.
Metastasis to the seminal vesicle is extremely rare for hepatocellular carcinoma (HCC). To our knowledge, it has been not reported in literature. The purpose of the present paper was to report a case of metastasis to the seminal vesicle after HCC resection, along with its histological features and immunohistochemical characteristics.
A 46-year-old Chinese man was admitted to our hospital due to abdominal distension. He had a history of HCC related to hepatitis B virus infection. Moreover, left partial hepatectomy was performed in another hospital 28 months ago, and right partial hepatectomy for HCC recurrence in our hospital 4 months ago. After resection, radiofrequency ablation therapy had been performed. About 27 months after the initial operation, contrast-enhanced computed tomography (CT) of the pelvic cavity revealed a mass with homogeneous enhancement in the seminal vesicle. Transrectal needle biopsy revealed a poorly differentiated adenocarcinoma. Therefore, seminal vesiculectomy was resected. The histological diagnosis of the removed tumor was compatible with the original HCC. Immunohistochemical examination demonstrated that the tumor cells were positive for glypican-3 (GPC3), alpha-fetoprotein (AFP), hepatocyte paraffin-1 (Hep Par 1), cytokeratin 18 (CK 18), and hepatocyte antigen, which confirmed that the seminal vesicle tumor was a metastatic tumor of HCC. However, CT subsequently revealed multiple metastatic foci in the abdominal and pelvic cavities in May 2009 and August 2009, respectively.
The seminal vesicle is an extremely rare metastatic site for HCC, and the prognosis is very poor. A combination of clinical and pathological features is necessary for a correct diagnosis, and primary tumor should be excluded before diagnosing metastatic foci.
肝癌（HCC）转移至精囊极其罕见。据我们所知，目前尚未有文献报道。本文旨在报道 1 例 HCC 切除术后转移至精囊的病例，并对其组织学特征和免疫组织化学特征进行描述。
一名 46 岁的中国男性因腹胀就诊。他患有乙型肝炎病毒感染相关的 HCC，并且 28 个月前曾在另一家医院行左半肝切除术，4 个月前在我院行右半肝切除术治疗 HCC 复发。术后行射频消融治疗。初次手术后约 27 个月，盆腔增强 CT 显示精囊内有均匀增强的肿块。经直肠针吸活检显示为低分化腺癌。因此行精囊切除术。切除肿瘤的组织学诊断与原始 HCC 一致。免疫组织化学检查显示肿瘤细胞 GPC3、甲胎蛋白（AFP）、肝石蜡-1（Hep Par 1）、细胞角蛋白 18（CK 18）和肝细胞抗原阳性，证实精囊肿瘤为 HCC 的转移性肿瘤。然而，2009 年 5 月和 2009 年 8 月 CT 分别显示腹部和盆腔有多个转移灶。
精囊是 HCC 极罕见的转移部位，预后极差。正确诊断需要结合临床和病理特征，在诊断转移灶之前应排除原发性肿瘤。
