Groupe Mémoire et Plasticité comportementale (GMPc) EA 4259, UFR des Sciences Pharmaceutiques, Université de Caen Basse-Normandie, 5 rue Vaubénard, 14032 Caen Cedex, France.
Behav Brain Res. 2011 Sep 12;222(1):134-40. doi: 10.1016/j.bbr.2011.03.046. Epub 2011 Apr 1.
Studies have shown that the blockade of 5-HT6 receptors (5-HT6R) can improve memory processes and reverse age-related spatial episodic like memory deficits. Since normal aging in the human is associated with a decline in episodic and working memory, we assessed the effect of the 5-HT6R blockade (SB-271046) on recognition memory (object recognition task) (a component of episodic like memory) in parallel to working memory (spontaneous alternation task in the T-maze) performances in young, adult, aged and senescent mice. Deficits in consolidation of non spatial recognition memory that were observed in 17- and 21-month-old mice were found to be reversed by 5-HT6R blockade. Deficits in working memory performances were only apparent as late as at 25 months of age; again, these deficits were reversed by 5-HT6R blockade. This study revealed in the mouse that, as in humans, working memory is more lately altered than recognition memory during aging and that such memory deficits could be counteracted by the use of 5-HT6R antagonists.
研究表明，阻断 5-羟色胺 6 受体（5-HT6R）可以改善记忆过程并逆转与年龄相关的空间情景记忆缺陷。由于人类的正常衰老与情景记忆和工作记忆的下降有关，我们评估了 5-HT6R 阻断（SB-271046）对年轻、成年、老年和衰老小鼠的识别记忆（物体识别任务）（情景记忆的一个组成部分）和工作记忆（T 迷宫中的自发交替任务）的影响。在 17 个月和 21 个月大的小鼠中观察到的非空间识别记忆巩固缺陷，通过 5-HT6R 阻断得到了逆转。工作记忆表现的缺陷仅在 25 个月大时才明显出现；同样，这些缺陷也被 5-HT6R 阻断所逆转。这项研究在小鼠中揭示了，与人类一样，在衰老过程中，工作记忆比识别记忆更容易受到影响，而使用 5-HT6R 拮抗剂可以对抗这种记忆缺陷。
