Rev Neurosci. 2014;25(3):417-27. doi: 10.1515/revneuro-2014-0013.
The 5-HT6 receptor (5-HT6R) is one of the most recently discovered serotonin receptors and has received much attention after observations showing its procognition properties. Indeed, 5-HT6R appears to be a promising target to treat cognitive decline, particularly via its modulatory function of cholinergic and glutamatergic systems. 5-HT6Rs are present mostly in the central nervous system, in brain structures known to be particularly involved in memory. Growing evidence suggests that blockade of 5-HT6R can not only improve memory processes in adult rodents but also reverse age-related and pharmacologically induced deficits. 5-HT6R blockade could also have a beneficial effect on neuronal plasticity. Regarding these findings, several 5-HT6R antagonists are currently going through clinical trials. This review provides an overview of the major findings arguing in favour of a role for 5-HT6R antagonists in developing treatment for cognitive disorders related to ageing and neurodegenerative diseases.
5-羟色胺 6 受体（5-HT6R）是最近发现的 5-羟色胺受体之一，在观察到其认知特性后受到了广泛关注。事实上，5-HT6R 似乎是治疗认知能力下降的一个很有前途的靶点，特别是通过其对胆碱能和谷氨酸能系统的调节作用。5-HT6R 主要存在于中枢神经系统中，存在于已知特别参与记忆的大脑结构中。越来越多的证据表明，5-HT6R 阻断不仅可以改善成年啮齿动物的记忆过程，而且可以逆转与年龄相关的和药物诱导的缺陷。5-HT6R 阻断也可能对神经元可塑性产生有益的影响。关于这些发现，目前有几种 5-HT6R 拮抗剂正在进行临床试验。这篇综述概述了支持 5-HT6R 拮抗剂在开发与衰老和神经退行性疾病相关的认知障碍治疗中的作用的主要发现。
