González M L, Usandizaga M, Alomar P, Salvá F, Martín F, Erroz M J, Lardinois R
Hospital Son Dureta, Palma de Mallorca, Spain.
Vaccine. 1990 Aug;8(4):402-5. doi: 10.1016/0264-410x(90)90102-r.
A recombinant hepatitis B vaccine was administered to high-risk hospital personnel by intramuscular (20 micrograms) or intradermal (2 micrograms) injections for the primary immunization (n = 69) with three doses and booster immunization (n = 51) with one dose. Basic vaccination performed intramuscularly gave rise to significantly higher seroconversion levels (97.2% versus 78.1%) and geometric mean titres of antibody (1649 versus 126 IUl-1) as compared with the intradermal route. Intradermal administration did not boost antibody titres in patients previously vaccinated intradermally. Adverse reactions were not serious or severe. The intramuscular route is recommended as the procedure of choice when vaccinating against hepatitis B.
一种重组乙型肝炎疫苗通过肌肉注射（20微克）或皮内注射（2微克）用于高危医院工作人员的初次免疫（n = 69），共接种三剂，以及加强免疫（n = 51），接种一剂。与皮内途径相比，肌肉注射进行的基础疫苗接种产生了显著更高的血清转化率（97.2%对78.1%）和抗体几何平均滴度（1649对126 IUl-1）。皮内给药并未提高先前皮内接种过疫苗患者的抗体滴度。不良反应不严重。在接种乙型肝炎疫苗时，推荐肌肉注射途径作为首选方法。
