Bailey Leonard L
Department of Cardiovascular and Thoracic Surgery, Loma Linda University Medical Center and Children's Hospital, Loma Linda, CA, USA.
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2011;14(1):98-100. doi: 10.1053/j.pcsu.2011.01.004.
Clinical heart transplantation was first accomplished by Christiaan Barnard in 1967. Infant heart transplantation was first attempted by Adrian Kantrowitz just 3 days later in New York. Sixteen years lapsed before neonatal transplantation was again attempted, first in London and then in Loma Linda, California in the summer and fall of 1984, respectively. The latter infant became known as "Baby Fae." Neither infant survived a month, but both produced an important impact through media exposure on the public consciousness. The idea of infant organ donation slowly developed traction. The first successful neonatal heart transplant occurred in Loma Linda on November 15, 1985. That recipient, born with hypoplastic left heart syndrome, is now 25 years old. Thereafter, the incidence of infant and pediatric heart transplantation gradually increased. Today, 350 to 450 transplants are reported annually to the Registry of the International Society for Heart and Lung Transplantation, 25% of which are in young infants. Norwood's staged-reconstruction for complex univentricular heart disease has markedly reduced the need for primary transplantation in very early life. Still, many potential young infant recipients are best treated in no other way.
1967年，克里斯蒂安·巴纳德首次完成了临床心脏移植手术。仅仅三天后，阿德里安·坎特罗维茨在纽约首次尝试进行婴儿心脏移植手术。16年后，才再次尝试进行新生儿心脏移植手术，分别于1984年夏、秋两季在伦敦和加利福尼亚州洛马林达市进行。后一名婴儿就是著名的“法伊宝宝”。两名婴儿均未能活过一个月，但通过媒体曝光，二者都在公众意识上产生了重大影响。婴儿器官捐献的理念逐渐获得了支持。1985年11月15日，洛马林达市成功进行了首例新生儿心脏移植手术。该接受者患有左心发育不全综合征，如今已25岁。此后，婴儿及小儿心脏移植的发病率逐渐上升。如今，每年向国际心肺移植协会登记处报告的移植手术有350至450例，其中25%是针对小婴儿的。诺伍德针对复杂单心室心脏病的分期重建手术显著减少了早期进行初次移植的必要性。尽管如此，许多潜在的小婴儿接受者仍没有其他更好的治疗方法。
