用于心脏异种移植的基因工程猪心脏的免疫生物学及临床应用
The immunobiology and clinical use of genetically engineered porcine hearts for cardiac xenotransplantation.
作者信息
Goerlich Corbin E, Singh Avneesh K, Griffith Bartley P, Mohiuddin Muhammad M
机构信息
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
出版信息
Nat Cardiovasc Res. 2022 Aug;1(8):715-726. doi: 10.1038/s44161-022-00112-x. Epub 2022 Aug 9.
Abstract
A summary of the scientific rationale of the advancements that led to the first genetically modified pig-to-human cardiac xenotransplantation is lacking in a complex and rapidly evolving field. Here, we aim to aid the general readership in the understanding of the gradual progression of cardiac (xeno)transplantation research, the immunobiology of cardiac xenotransplantation (including the latest immunosuppression, cardiac preservation and genetic engineering required for successful transplantation) and the regulatory landscape related to the clinical application of cardiac xenotransplantation for people with end-stage heart failure. Finally, we provide an overview of the outcomes and lessons learned from the first genetically modified pig-to-human cardiac heart xenotransplantation.
摘要
在这个复杂且快速发展的领域，缺乏对促成首例基因编辑猪到人的心脏异种移植进展的科学原理的总结。在此，我们旨在帮助普通读者理解心脏（异种）移植研究的渐进过程、心脏异种移植的免疫生物学（包括成功移植所需的最新免疫抑制、心脏保存和基因工程）以及与终末期心力衰竭患者心脏异种移植临床应用相关的监管情况。最后，我们概述了首例基因编辑猪到人的心脏异种移植的结果及经验教训。
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