Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, and Histopathology Department, Leicester Royal Infirmary, University Hospital of Leicester NHS Trust, Leicester, United Kingdom.
Fertil Steril. 2011 Jun;95(7):2228-35, 2235.e1. doi: 10.1016/j.fertnstert.2011.02.051. Epub 2011 Mar 27.
To test the hypothesis that the expression of the different isoforms of the estrogen receptor alpha (ER-α) and beta (ER-β) and the progesterone receptor A (PR-A) and B (PR-B) would be differentially modulated in uteri with adenomyosis compared with controls and that modulation would be related to the menstrual cycle.
Case control, blinded comparison.
University department.
PATIENT(S): 54 premenopausal women with and 35 without uterine adenomyosis as the sole pathology.
INTERVENTION(S): Multiple samples studied using immunohistochemistry for estrogen and progesterone receptors.
MAIN OUTCOME MEASURE(S): Histomorphometric analysis of receptor expression.
RESULT(S): The ER-α expression in the adenomyotic endometrium was different from that of the normal endometrium and the foci in the midsecretory phase of the cycle, but expression of ER-α in the inner and outer myometrium was not statistically significantly different. The ER-β expression was statistically significantly elevated in the adenomyotic functionalis gland during the proliferative phase and throughout the myometrium across the entire menstrual cycle. Expression of PR-A was similar to that of PR-B, with reduced expression in the basalis stroma, and inner and outer myometrium in the adenomyotic samples. The pattern of ER-β, PR-A, and PR-B expression was similar in the endometrial basalis and adenomyotic foci.
CONCLUSION(S): These data suggest ER-β expression and the lack of PR expression are related to the development and/or progression of adenomyosis and might explain the poor response of adenomyosis-associated menstrual symptoms to progestational agents.
验证假说，即不同亚型的雌激素受体α（ER-α）和β（ER-β）以及孕激素受体 A（PR-A）和 B（PR-B）在患有子宫腺肌病的子宫中的表达会与对照组不同，且这种调节与月经周期有关。
病例对照，盲法比较。
大学系。
患者（s）：54 名有和 35 名无子宫腺肌病的绝经前妇女，其唯一病理为子宫腺肌病。
干预（s）：使用免疫组织化学法研究雌激素和孕激素受体的多个样本。
主要观察指标（s）：受体表达的组织形态计量学分析。
结果（s）：在腺肌病子宫内膜中，ER-α的表达与正常子宫内膜和周期中分泌中期的病灶不同，但内、外肌层的 ER-α表达无统计学差异。在增殖期和整个月经周期中，ER-β在腺肌病功能性腺体中的表达明显升高。PR-A 的表达与 PR-B 相似，在腺肌病样本中，基底层基质、内肌层和外肌层的表达减少。ER-β、PR-A 和 PR-B 的表达模式在子宫内膜基底层和腺肌病病灶中相似。
结论（s）：这些数据表明，ER-β表达和 PR 表达缺失与子宫腺肌病的发生和/或进展有关，这可能解释了腺肌病相关月经症状对孕激素药物反应不佳的原因。
