Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.
J Neurol Sci. 2011 Jun 15;305(1-2):149-51. doi: 10.1016/j.jns.2011.03.009. Epub 2011 Mar 27.
We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin's lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions.
我们描述了一例明确的肠道病毒 71 型脑膜炎病例，该病例并发于非霍奇金淋巴瘤的单克隆抗 CD20 抗体治疗。B 细胞耗竭是一种在不断扩大的血液系统和炎症性疾病治疗策略中非常有效的方法，它会损害中和抗体介导的肠道病毒清除。在非流行地区，易感人群的增加，使新兴的神经营养性病毒（如肠道病毒 71 型）的全球威胁加剧。
