Pediatric Hematology and Oncology Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
Leuk Res. 2011 Aug;35(8):1001-7. doi: 10.1016/j.leukres.2011.03.006. Epub 2011 Mar 27.
Rearrangements in MLL (MLL-r) are common within very young children with leukemia and affect the prognosis and treatment. Previous studies have suggested the use of the NG2 molecule as a marker for MLL-r but these studies were performed using a small number of infants. We analyzed 148 patients (all less than 24 months, 86 less than 12 months) from various centers in Brazil to determine the predictive power of NG2 within that cohort. We show that NG2 can be used for MLL-r prediction; however, proper staff training and standardized sampling procedures are essential when receiving samples from multiple centers as the accuracy of the prediction varies greatly on a per center basis.
MLL（MLL-r）重排常见于非常年幼的白血病患儿，影响预后和治疗。先前的研究表明，NG2 分子可用作 MLL-r 的标志物，但这些研究是使用少数婴儿进行的。我们分析了来自巴西不同中心的 148 例患者（均小于 24 个月，86 例小于 12 个月），以确定 NG2 在该队列中的预测能力。我们表明，NG2 可用于 MLL-r 预测；然而，当从多个中心接收样本时，适当的人员培训和标准化采样程序是必不可少的，因为预测的准确性在每个中心之间差异很大。
