Pearson S J, Heathfield K W, Reynolds G P
Department of Biomedical Science, University of Sheffield, United Kingdom.
J Neural Transm Gen Sect. 1990;81(3):241-6. doi: 10.1007/BF01245046.
Neurochemical correlates of chorea in Huntington's disease were studied using striatal and pallidal tissue taken post mortem from patients with mild and severe chorea. While GABA was decreased in all these areas in Huntington's disease, patients with mild chorea had significantly less GABA in the medial pallidum than did those with severe chorea. There was no relationship between the degree of chorea and concentrations of dopamine or its metabolite. Thus the chorea of Huntington's disease may relate to the balance of residual GABAergic innervation between specific areas of the basal ganglia, consistent with primate models of dyskinesias.
利用从患有轻度和重度舞蹈症的亨廷顿病患者死后获取的纹状体和苍白球组织，对亨廷顿病中舞蹈症的神经化学相关性进行了研究。虽然在亨廷顿病的所有这些区域中γ-氨基丁酸（GABA）都减少了，但轻度舞蹈症患者在内侧苍白球中的GABA明显少于重度舞蹈症患者。舞蹈症的程度与多巴胺或其代谢产物的浓度之间没有关系。因此，亨廷顿病的舞蹈症可能与基底神经节特定区域之间残余的GABA能神经支配平衡有关，这与运动障碍的灵长类动物模型一致。
