Reynolds G P, Pearson S J
Neurosci Lett. 1987 Jul 22;78(2):233-8. doi: 10.1016/0304-3940(87)90639-2.
gamma-Aminobutyric acid (GABA), glutamate and serotonin (5-HT), along with its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA), have been measured in 4 brain regions taken post-mortem from patients with Huntington's disease and from control subjects. GABA was found to be significantly reduced, not only in the basal ganglia, but also in the cortex and hippocampus. Glutamate was also reduced in all regions except the pallidum, and thus was unrelated to the GABA deficit which was greatest in this area. 5-HT and 5-HIAA were significantly increased in all areas except the hippocampus.
已对亨廷顿舞蹈症患者及对照受试者死后获取的4个脑区中的γ-氨基丁酸（GABA）、谷氨酸和血清素（5-羟色胺，5-HT）及其主要代谢产物5-羟吲哚乙酸（5-HIAA）进行了测量。结果发现，不仅基底神经节中的GABA显著减少，而且皮质和海马体中的GABA也显著减少。除苍白球外，所有脑区的谷氨酸也均减少，因此谷氨酸减少与该区域最为明显的GABA缺乏并无关联。除海马体外，所有脑区的5-HT和5-HIAA均显著增加。
