Department of Endocrinology and Metabolism, The First Affiliated Hospital, China Medical University, No 155 Nanjing Bei Street, Heping District, Shenyang, People's Republic of China.
Eur J Endocrinol. 2011 Jun;164(6):943-50. doi: 10.1530/EJE-10-1041. Epub 2011 Mar 28.
With the introduction of iodized salt worldwide, more and more people are exposed to more than adequate iodine intake levels with median urinary iodine excretion (MUI 200-300 μg/l) or excessive iodine intake levels (MUI >300 μg/l). The objective of this study was to explore the associations between more than adequate iodine intake levels and the development of thyroid diseases (e.g. thyroid dysfunction, thyroid autoimmunity, and thyroid structure) in two Chinese populations.
A population-based cross-sectional study was conducted in two areas in which people are exposed to different levels of iodine intake (Rongxing, MUI 261 μg/l; Chengshan, MUI 145 μg/l). A total of 3813 individuals were recruited by random sampling. Thyroid hormones, thyroid autoantibodies in serum, and iodine levels in urine were measured. B-mode ultrasonography of the thyroid was also performed for each participant.
The prevalence of subclinical hypothyroidism was significantly higher for subjects who live in Rongxing than those who live in Chengshan (5.03 vs 1.99%, P<0.001). The prevalence of positive anti-thyroid peroxidase antibody (TPOAb) and positive anti-thyroglobulin antibody (TgAb) was significantly higher for subjects in Rongxing than those in Chengshan (TPOAb: 10.64 vs 8.4%, P=0.02; TgAb: 10.27 vs 7.93%, P=0.01). The increase in thyroid antibodies was most pronounced in the high concentrations of TPOAb (TPOAb: ≥500 IU/ml) and low concentrations of TgAb (TgAb: 40-99 IU/ml) in Rongxing.
More than adequate iodine intake could be a public health concern in terms of thyroid function and thyroid autoimmunity in the Chinese populations.
随着全球范围内碘盐的引入，越来越多的人接触到了足够甚至过量的碘摄入量，尿碘中位数（MUI 200-300μg/l）或碘摄入量过高（MUI>300μg/l）。本研究旨在探讨中国两个人群中碘摄入过多与甲状腺疾病（如甲状腺功能障碍、甲状腺自身免疫和甲状腺结构）发展之间的关系。
在两个碘摄入水平不同的地区（荣兴，MUI 261μg/l；成山，MUI 145μg/l）进行了一项基于人群的横断面研究。通过随机抽样共招募了 3813 名个体。测量了血清甲状腺激素、甲状腺自身抗体和尿碘水平。还对每位参与者进行了甲状腺的 B 型超声检查。
荣兴居民亚临床甲状腺功能减退症的患病率明显高于成山居民（5.03%比 1.99%，P<0.001）。荣兴居民的甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TgAb）阳性率明显高于成山居民（TPOAb：10.64%比 8.4%，P=0.02；TgAb：10.27%比 7.93%，P=0.01）。在 TPOAb 高浓度（TPOAb：≥500IU/ml）和 TgAb 低浓度（TgAb：40-99IU/ml）的情况下，甲状腺抗体的增加最为明显。
在中国人群中，碘摄入过多可能会对甲状腺功能和甲状腺自身免疫产生公共健康影响。
