MacKay S A
J Cell Sci. 1978 Oct;33:1-16. doi: 10.1242/jcs.33.1.1.
The aggregation phase of development of the cellular slime mould Dictyostelium discoideum is simulated on a computer. The simulation is performed in 2 dimensions, and produces animated graphical output similar to time-lapse films. It is based on observations of cell behaviour as expressed by a set of rules for each cell, involving cell movement and release of and response to chemical signals. Following these rules, the simulation has reproduced many observed aggregation patterns: propagating waves of cell movement; formation of branching streams; entrainment of slower centres; and spiral centre formation. The simulation has proved to be an important adjunct to experimental work.
利用计算机模拟了细胞黏菌盘基网柄菌发育的聚集阶段。模拟在二维空间中进行，并产生类似于延时电影的动画图形输出。它基于对细胞行为的观察，通过为每个细胞设定一组规则来体现，这些规则涉及细胞运动以及化学信号的释放和响应。遵循这些规则，模拟再现了许多观察到的聚集模式：细胞运动的传播波；分支流的形成；较慢中心的夹带；以及螺旋中心的形成。该模拟已被证明是实验工作的重要辅助手段。
