Gover Ayala, Bader David, Weinger-Abend Martha, Chystiakov Irena, Miller Elka, Riskin Arieh, Hochwald Ori, Beni-Adani Liana, Tirosh Emanuel, Kugelman Amir
Department of Neonatology, Bnai Zion Medical Center affiliated with Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Isr Med Assoc J. 2011 Jan;13(1):9-13.
The rate of brain abnormalities in asymptomatic term neonates varies substantially in previous studies. Some of these rates may justify general screening of healthy newborns by head ultrasound (HUS).
To assess the incidence of intracranial abnormalities among asymptomatic term newborns with HUS and to detect high-risk populations that might need such screening.
This was a prospective study in 493 term newborns who underwent HUS and a neurological evaluation during the first 3 days of life. The neurological examination results were unknown to the sonographist and the examiner was blinded to the HUS findings. The abnormal HUS findings were classified as significant or non-significant according to the current literature.
Abnormal HUS was found in 11.2% of the neonates. Significant findings were noted in 3.8% of the infants. There was no association between non-structural HUS findings (hemorrhage or echogenicity) and mode of delivery. There was no relationship between any HUS abnormality and birth weight, head circumference and maternal age, ethnicity, education or morbidity. The rate of abnormal neurological, hearing or vision evaluation in infants with a significant abnormal HUS (5.2%) was comparable to the rate in infants with normal or non-significant findings on HUS (3.1%).
There is no indication for routine HUS screening in apparently healthy term neonates due to the relatively low incidence of significant brain abnormalities in these infants in our population.
在以往的研究中,无症状足月儿脑异常的发生率差异很大。其中一些发生率可能为通过头部超声(HUS)对健康新生儿进行常规筛查提供依据。
评估无症状足月儿接受HUS检查时颅内异常的发生率,并检测可能需要此类筛查的高危人群。
这是一项对493名足月儿进行的前瞻性研究,这些足月儿在出生后3天内接受了HUS检查和神经学评估。超声检查医师不知道神经学检查结果,检查者也不知道HUS检查结果。根据当前文献,将异常的HUS检查结果分为显著异常或非显著异常。
11.2%的新生儿HUS检查结果异常。3.8%的婴儿有显著异常发现。HUS非结构性检查结果(出血或回声)与分娩方式之间无关联。任何HUS异常与出生体重、头围、母亲年龄、种族、教育程度或发病率之间均无关系。HUS检查结果显著异常的婴儿中,神经、听力或视力评估异常的发生率(5.2%)与HUS检查结果正常或非显著异常的婴儿中该发生率(3.1%)相当。
在我们的研究人群中,由于这些婴儿中显著脑异常的发生率相对较低,因此没有迹象表明对明显健康的足月儿进行常规HUS筛查是必要的。