Positive temporal sharp waves in preterm infants with and without brain ultrasound lesions.

作者信息

Castro Conde José Ramón, Martínez Eduardo Doménech, Campo Candelaria González, Pérez Arturo Méndez, McLean Michael Lee

机构信息

Department of Pediatrics, Faculty of Medicine, University of the La Laguna, Ofra S/N, La Laguna, S/C Tenerife 38320, Spain.

出版信息

Clin Neurophysiol. 2004 Nov;115(11):2479-88. doi: 10.1016/j.clinph.2004.05.028.

DOI:10.1016/j.clinph.2004.05.028

PMID:15465435

Abstract

OBJECTIVE

Clinical significance of neonatal positive temporal sharp waves (PTS) is controversial. The aim of this work is to study (1) PTS incidence in preterm infants with or without major ultrasound lesion (MUL) per gestational age (GA), and (2) the relationship between PTS in both sleep states and other electroencephalographic (EEG) findings with poor prognoses.

METHODS

97 preterm infants of <27-36 weeks GA, and 12 full-term healthy infants were presented. Prospective study included (1) neurodevelopmental assessment at 40-42 weeks conceptional age (CA), (2) serial neurosonography, and (3) EEG recording at postnatal week 1, 2, 4 and at 40-42 weeks CA.

RESULTS

In 50 neonates without MUL, peak PTS was at 31-32 weeks GA. In 47 neonates with MUL, PTS increased significantly from week 2 after birth, descending at the 4th. Neonates of <33 weeks GA with MUL showed significantly increased PTS at term. A significant relationship was found between PTS and other EEG abnormalities with poor neurologic prognoses. PTS incidence varied with sleep states, being predominant in indeterminate sleep in neonates with MUL.

CONCLUSIONS

PTS increased significantly in infants with MUL, mainly at week 2 of postnatal life, persisting high until term CA, and correlated with other abnormal EEG findings.