Futagami M, Yokoyama Y, Mizunuma H
Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, Japan.
Eur J Gynaecol Oncol. 2011;32(1):99-102.
Small cell carcinoma of the uterine cervix is a rare cervical carcinoma that advances early and is associated with a poor prognosis. We present a case of this disease which invaded the parametrium and metastasized to the pelvic lymph node. The patient underwent postoperative concurrent chemoradiotherapy (CCRT) followed by maintenance chemotherapy and obtained long-term survival.
A 26-year-old patient, who had conceived on two occasions without giving birth and had smoked for ten years, underwent radical hysterectomy with a diagnosis of Stage Ibl cervical carcinoma in December 2006. The patient showed parametrial invasion, and metastasis to the left external iliac node and vaginal stump. With a diagnosis of pT2bN1M0, the patient underwent CCRT with weekly nedaplatin as postoperative therapy. For the maintenance chemotherapy, from May 2007, ten courses of PE therapy (CDDP, 15 mg/body; VP-16, 100 mg/body x 3) were performed. No recurrent signs have been observed for 39 months after the first operation.
PE therapy may be useful as maintenance therapy, although there are no established treatments for small cell carcinoma of the uterine cervix.
宫颈小细胞癌是一种罕见的宫颈癌，早期进展且预后较差。我们报告一例该疾病侵犯宫旁组织并转移至盆腔淋巴结的病例。该患者接受了术后同步放化疗（CCRT），随后进行维持化疗并获得了长期生存。
一名26岁患者，曾两次怀孕但未生育，有十年吸烟史，2006年12月因诊断为Ib1期宫颈癌接受了根治性子宫切除术。患者显示出宫旁组织侵犯，以及左侧髂外淋巴结和阴道残端转移。诊断为pT2bN1M0，患者术后接受了以每周奈达铂为基础的CCRT治疗。对于维持化疗，从2007年5月开始，进行了十个疗程的PE治疗（顺铂，15mg/体；依托泊苷，100mg/体×3）。首次手术后39个月未观察到复发迹象。
尽管宫颈小细胞癌尚无既定的治疗方法，但PE治疗作为维持治疗可能是有用的。
