Suh Y J, Kil D S, Chung K S, Abdullayev E, Lvov Y M, Mongayt D
Mineral Resources Research Division, Korea Institute of Geoscience and Mineral Resources, Daejeon 305-350, Korea.
J Nanosci Nanotechnol. 2011 Jan;11(1):661-5. doi: 10.1166/jnn.2011.3194.
Natural halloysite nanotubes with a 15-nm internal lumen and a 50 nm outer diameter were investigated as a nanocontainer for the loading and extended release of glycerol for cosmetic applications. Cytotoxicity testing of the halloysite was conducted on 3T3 and MCF-7 cells, and the tubules showed no toxic effect on the cells for over 48 h. The capability of halloysite for loading glycerol was higher with the USA halloysite than with the New Zealand's, being approximately 20% and 2.3% by weight, respectively. The total elapsed time for releasing glycerol from the nanotubes exceeded 20 h. To further retard the glycerol release rate, the halloysite samples filled with glycerol were coated with several alternate layers of polyethyleneimine and polyacrylic acid. The release rate remained at the same level, however, probably due to the low molecular weight of the polyelectrolytes and the high solubility of glycerol in water.
研究了内径为15纳米、外径为50纳米的天然埃洛石纳米管作为纳米容器用于化妆品应用中甘油的负载和缓释。对埃洛石进行了3T3和MCF - 7细胞的细胞毒性测试，结果表明，在超过48小时的时间里，这些小管对细胞没有毒性作用。美国埃洛石负载甘油的能力高于新西兰埃洛石，分别约为20%和2.3%（重量）。从纳米管中释放甘油的总时间超过20小时。为了进一步延缓甘油的释放速率，用聚乙烯亚胺和聚丙烯酸的交替层对填充有甘油的埃洛石样品进行了包覆。然而，释放速率保持在同一水平，这可能是由于聚电解质的低分子量以及甘油在水中的高溶解度所致。
