Dvey-Aharon Zack, Fogelson Noa, Peled Avi, Intrator Nathan
Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel.
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel; Department of Psychology, University of A Coruña, La Coruña, Spain.
PLoS One. 2015 Apr 2;10(4):e0123033. doi: 10.1371/journal.pone.0123033. eCollection 2015.
Electroencephalographic (EEG) analysis has emerged as a powerful tool for brain state interpretation and diagnosis, but not for the diagnosis of mental disorders; this may be explained by its low spatial resolution or depth sensitivity. This paper concerns the diagnosis of schizophrenia using EEG, which currently suffers from several cardinal problems: it heavily depends on assumptions, conditions and prior knowledge regarding the patient. Additionally, the diagnostic experiments take hours, and the accuracy of the analysis is low or unreliable. This article presents the "TFFO" (Time-Frequency transformation followed by Feature-Optimization), a novel approach for schizophrenia detection showing great success in classification accuracy with no false positives. The methodology is designed for single electrode recording, and it attempts to make the data acquisition process feasible and quick for most patients.
脑电图(EEG)分析已成为解释大脑状态和进行诊断的有力工具,但并非用于精神障碍的诊断;这可能是由于其空间分辨率低或深度敏感性不足所致。本文关注的是利用脑电图诊断精神分裂症,目前这一方法存在几个主要问题:它严重依赖于关于患者的假设、条件和先验知识。此外,诊断实验耗时数小时,且分析的准确性较低或不可靠。本文提出了“TFFO”(时频变换后进行特征优化),这是一种用于精神分裂症检测的新方法,在分类准确性方面取得了巨大成功,且无假阳性。该方法专为单电极记录设计,旨在使大多数患者的数据采集过程可行且快速。