Schouten H C, Sanger W G, Weisenburger D D, Armitage J O
Department of Internal Medicine, University Hospital Maastricht, The Netherlands.
Eur J Cancer. 1990;26(5):618-22. doi: 10.1016/0277-5379(90)90092-8.
In contrast to non-Hodgkin's lymphomas (NHL) with a B-cell phenotype, almost no data have been reported dealing with correlations between chromosomal abnormalities and characteristics of the disease in patients with T-cell NHL. In a retrospective analysis we studied all patients with a non-cutaneous T-cell NHL and chromosomal abnormalities that were evaluated at our institution; 20 patients could be identified. Numerical abnormalities involving chromosomes 3, 4, 5, 22 and X were observed most frequently. Structural abnormalities involved mainly the breakpoints 1q22-25, 6q23 and 11q13. There appeared to be an association between +7, breakpoints 2p23-24, 4p14-15, 8q21 and the presence of extranodal disease. All patients with +7 had a diffuse mixed histology. Patients with +2, +3, +11, +17, +18, +20 or breakpoint 1q22-25 had an immunoblastic lymphoma and patients with breakpoints 9q32-34 or 14q12 had a lymphoblastic lymphoma. No correlations were observed between chromosomal abnormalities and response to therapy, survival or phenotypic markers. Abnormalities involving the chromosomes containing the T-cell receptor genes and T-cell markers were infrequent. Several breakpoints were identified that correlate with already described oncogenes.
与具有B细胞表型的非霍奇金淋巴瘤（NHL）不同，几乎没有关于T细胞NHL患者染色体异常与疾病特征之间相关性的报道。在一项回顾性分析中，我们研究了在我们机构接受评估的所有非皮肤T细胞NHL和染色体异常患者；共识别出20例患者。最常观察到涉及3号、4号、5号、22号染色体和X染色体的数目异常。结构异常主要涉及断点1q22 - 25、6q23和11q13。+7、断点2p23 - 24、4p14 - 15、8q21与结外疾病的存在之间似乎存在关联。所有+7的患者均为弥漫性混合组织学。+2、+3、+11、+17、+18、+20或断点1q22 - 25的患者患有免疫母细胞性淋巴瘤，断点9q32 - 34或14q12的患者患有淋巴母细胞性淋巴瘤。未观察到染色体异常与治疗反应、生存率或表型标志物之间的相关性。涉及含有T细胞受体基因和T细胞标志物的染色体异常很少见。确定了几个与已描述的癌基因相关的断点。
