van 't Veer M B
Dr. Daniel den Hoed Cancer Centre, Rotterdam.
Neth J Med. 1990 Aug;37(1-2):37-43.
In non-Hodgkin's lymphoma, chromosome abnormalities are found that are characteristic for the type of the lymphoma. These chromosomal abnormalities provide a tumour-specific marker and seem to play a role in the oncogenesis of the lymphoma. Chromosome 14 is involved in many lymphomas. The immunoglobulin heavy chain gene and the alpha and delta chain genes for the T cell receptor are located on this chromosome, genes which are essential for the function of B or T lymphocytes. These genes are involved in the specific translocations seen in non-Hodgkin's lymphoma. Their role and the role of oncogenes in the oncogenesis of non-Hodgkin's lymphoma are discussed. The oncogene tcl-1 is also located on chromosome 14.
在非霍奇金淋巴瘤中，可发现具有该淋巴瘤类型特征的染色体异常。这些染色体异常提供了一种肿瘤特异性标志物，并且似乎在淋巴瘤的肿瘤发生过程中发挥作用。14号染色体与许多淋巴瘤相关。免疫球蛋白重链基因以及T细胞受体的α和δ链基因位于这条染色体上，这些基因对于B或T淋巴细胞的功能至关重要。这些基因参与了非霍奇金淋巴瘤中出现的特异性易位。文中讨论了它们的作用以及癌基因在非霍奇金淋巴瘤肿瘤发生中的作用。癌基因tcl-1也位于14号染色体上。
