血液系统恶性肿瘤中的骨髓基质——无辜的旁观者。
The bone marrow stroma in hematological neoplasms--a guilty bystander.
机构信息
Department of Human Pathology, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy.
出版信息
Nat Rev Clin Oncol. 2011 Mar 29;8(8):456-66. doi: 10.1038/nrclinonc.2011.31.
Abstract
In the setting of hematological neoplasms, changes in the bone marrow (BM) stroma might arise from pressure exerted by the neoplastic clone in shaping a supportive microenvironment, or from chronic perturbation of the BM homeostasis. Under such conditions, alterations in the composition of the BM stroma can be profound, and could emerge as relevant prognostic factors. In this Review, we delineate the multifaceted contribution of the BM stroma to the pathobiology of several hematological neoplasms, and discuss the impact of stromal modifications on the natural course of these diseases. Specifically, we highlight the involvement of BM stromal components in lymphoid and myeloid malignancies, and present the most relevant processes responsible for remodeling the BM stroma. The role of bystander BM stromal elements in the setting of hematological neoplasms is discussed, strengthening the rationale for treatment strategies that target the BM stroma.
摘要
在血液系统恶性肿瘤中，骨髓（BM）基质的变化可能源于肿瘤克隆对支持性微环境的塑造所产生的压力，也可能源于 BM 内稳态的慢性紊乱。在这种情况下，BM 基质的组成可能会发生深刻的变化，并可能成为相关的预后因素。在这篇综述中，我们描述了 BM 基质对几种血液系统恶性肿瘤的病理生物学的多方面贡献，并讨论了基质改变对这些疾病自然病程的影响。具体来说，我们强调了 BM 基质成分在淋巴和髓系恶性肿瘤中的作用，并介绍了导致 BM 基质重塑的最相关过程。还讨论了血液系统恶性肿瘤中旁观者 BM 基质成分的作用，这为针对 BM 基质的治疗策略提供了合理依据。
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