Wong Sing Wan, Lenzini Stephen, Shin Jae-Won
Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA and Department of Bioengineering, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
APL Bioeng. 2018 May 22;2(3):031802. doi: 10.1063/1.5025689. eCollection 2018 Sep.
It is increasingly appreciated that physical forces play important roles in cancer biology, in terms of progression, invasiveness, and drug resistance. Clinical progress in treating hematological malignancy and in developing cancer immunotherapy highlights the role of the hematopoietic system as a key model in devising new therapeutic strategies against cancer. Understanding mechanobiology of the hematopoietic system in the context of cancer will thus yield valuable fundamental insights that can information about novel cancer therapeutics. In this perspective, biophysical insights related to blood cancer are defined and detailed. The interactions with immune cells relevant to immunotherapy against cancer are considered and expounded, followed by speculation of potential regulatory roles of mesenchymal stromal cells (MSCs) in this complex network. Finally, a perspective is presented as to how insights from these complex interactions between matrices, blood cancer cells, immune cells, and MSCs can be leveraged to influence and engineer the treatment of blood cancers in the clinic.
人们越来越认识到物理力在癌症生物学的进展、侵袭性和耐药性方面发挥着重要作用。在治疗血液系统恶性肿瘤和开发癌症免疫疗法方面的临床进展凸显了造血系统作为设计新型抗癌治疗策略的关键模型的作用。因此，了解癌症背景下造血系统的机械生物学将产生有价值的基本见解，可为新型癌症治疗提供信息。从这个角度出发，定义并详细阐述了与血癌相关的生物物理见解。考虑并阐述了与癌症免疫疗法相关的免疫细胞相互作用，随后推测了间充质基质细胞（MSC）在这个复杂网络中的潜在调节作用。最后，展望了如何利用基质、血癌细胞、免疫细胞和MSC之间这些复杂相互作用的见解来影响和设计临床血癌治疗。
