Randerath W J
Institut für Pneumologie an der Universität Witten/Herdecke, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf- und Beatmungsmedizin, Krankenhaus Bethanien.
Dtsch Med Wochenschr. 2011 Apr;136(14):706-9. doi: 10.1055/s-0031-1274569. Epub 2011 Mar 29.
Diagnosis and treatment of sleep related breathing disorders have become an essential challenge of internal medicine. They are highly important clinically because of the impairment of daytime performance, attention and concentration with elevated risk of accidents in workplace and traffic and because of their consequences on cardiovascular and metabolic disorders. The obstructive sleep apnoea syndrome (OSAS) has proven to be one of the most important risk factors for arteriosclerosis, especially in the cerebral vessels. OSAS induces arterial hypertention and increases mortality due to cardiovascular diseases. Sleep related breathing disorders induce hyperglycemia and dyslipidemia. OSAS and the metabolic syndrome increase the cardiovascular risk additively. Moreover, cardiac disorders, such as arterial hypertention, heart failure and arterial fibrillation, can induce central breathing disturbances. This impairs the prognosis of affected patients substantially. Atypical symptoms of obstructive sleep apnoea (daytime sleepiness, snoring, witnessed apnoea) are often absent in these patients. In contrast patients often suffer from fatigue, reduced daytime performance, and depression which is a major challenge to diagnosis. This review presents new data on these aspects. Moreover, the association of sleep apnoea and pulmonary embolism and the question of optimal sleep duration are addressed.
睡眠相关呼吸障碍的诊断和治疗已成为内科医学的一项重要挑战。它们在临床上非常重要,因为会损害白天的工作表现、注意力和专注力,增加在工作场所和交通中发生事故的风险,还因为它们会对心血管和代谢紊乱产生影响。阻塞性睡眠呼吸暂停综合征(OSAS)已被证明是动脉硬化的最重要危险因素之一,尤其是在脑血管方面。OSAS会导致动脉高血压,并增加心血管疾病导致的死亡率。睡眠相关呼吸障碍会导致高血糖和血脂异常。OSAS与代谢综合征会叠加增加心血管风险。此外,心脏疾病,如动脉高血压、心力衰竭和房颤,可导致中枢性呼吸障碍。这会严重损害受影响患者的预后。这些患者通常没有阻塞性睡眠呼吸暂停的典型症状(白天嗜睡、打鼾、观察到的呼吸暂停)。相反,患者常出现疲劳、白天工作表现下降和抑郁,这对诊断构成重大挑战。本综述介绍了这些方面的新数据。此外,还讨论了睡眠呼吸暂停与肺栓塞的关联以及最佳睡眠时间的问题。