兔眼旁路滤过术后使用示踪剂对引流途径的形态学研究。
Morphologic study of the drainage pathway using a tracer after a bypass filtering procedure in rabbit eyes.
作者信息
Lei Jianqin, Sun Naixue, Zhao Xiaoge, Kang Qianyan, Chen Li, Fan Xiaojuan
机构信息
Eye Department of the 1st Affiliated Hospital of the Medical College of Xi'an Jiaotong University, Xi'an, Shannxi, China.
出版信息
Ophthalmic Surg Lasers Imaging. 2011 May-Jun;42(3):254-62. doi: 10.3928/15428877-20110324-02. Epub 2011 Mar 31.
BACKGROUND AND OBJECTIVE
To study the drainage pathway using a tracer after a modified filtering surgery in rabbit eyes.
MATERIALS AND METHODS
The authors performed trabeculectomy combined with deep sclerectomy on one eye (TS group) and trabeculectomy on the other eye (T group) of 20 rabbits. Cationic ferritin was injected intracamerally just before killing the rabbits at postsurgical week 2, 4, 8, 12, or 24. The opposite side of the surgical site was used as the control. Histologic study was conducted under light microscopy.
RESULTS
In both groups, significantly more intrascleral and episcleral drainage vessels were observed than in the paired controls (P < .001). Intrascleral drainage canals were more often manifested in the TS group than in the T group (P < .05), especially after week 12.
CONCLUSION
Intrascleral and episcleral outflow were the main drainage routes after filtering surgeries in this model. Compared with trabeculectomy, the modified surgery was superior for forming an intrascleral "bleb" and seemed to be better maintained at a later stage.
背景与目的
研究兔眼改良滤过性手术后使用示踪剂的引流途径。
材料与方法
对20只兔的一只眼施行小梁切除术联合深层巩膜切除术（TS组），另一只眼施行小梁切除术（T组）。在术后第2、4、8、12或24周处死兔子前，向眼内注射阳离子铁蛋白。手术部位的对侧作为对照。在光学显微镜下进行组织学研究。
结果
两组中，巩膜内和巩膜上引流血管均显著多于配对对照（P <.001）。巩膜内引流管在TS组比T组更常见（P <.05），尤其是在第12周后。
结论
在该模型中，巩膜内和巩膜上流出是滤过性手术后的主要引流途径。与小梁切除术相比，改良手术在形成巩膜内“泡”方面更具优势，且后期似乎维持得更好。
Zotero 插件