Kawase K, Nishimura K, Yamamoto T, Jikihara S, Kitazawa Y
Dept of Ophthalmology, Gifu University School of Medicine, Japan.
Ophthalmic Surg. 1993 Jan;24(1):24-7.
We measured aqueous flare in 16 glaucomatous eyes after trabeculectomy in which 5-fluorouracil (5-FU) or mitomycin C (MMC) had been used as an adjunctive therapy. The eyes were divided into a 5-FU and an MMC group, matched for factors that might influence the postoperative inflammatory response to intraocular surgery. Seven eyes of seven patients received subconjunctival injections of 5-FU (50 mg in 2 weeks) and nine eyes of nine patients were given 0.2 mg/0.5 mL MMC intraoperatively. The aqueous flare converted to an albumin concentration (mg/dL) was significantly higher in the 5-FU group than in the MMC group (359.6 +/- 113.8 mg/dL and 143.2 +/- 46.7 mg/dL, respectively; Mann-Whitney U test, P < .05) on the second postoperative day. Intraoperative MMC appears to be no more harmful to the blood-aqueous barrier than 5-FU.
我们对16只青光眼患者小梁切除术后眼内房水闪光进行了测量，这些患者术中使用了5-氟尿嘧啶（5-FU）或丝裂霉素C（MMC）作为辅助治疗。将这些眼睛分为5-FU组和MMC组，根据可能影响眼内手术术后炎症反应的因素进行匹配。7例患者的7只眼接受了结膜下注射5-FU（2周内50mg），9例患者的9只眼术中给予0.2mg/0.5mL MMC。术后第二天，5-FU组转化为白蛋白浓度（mg/dL）的房水闪光明显高于MMC组（分别为359.6±113.8mg/dL和143.2±46.7mg/dL；Mann-Whitney U检验，P<0.05）。术中MMC对血-房水屏障的损害似乎并不比5-FU更大。
