9例儿童交替性偏瘫患者的临床特征

Clinical features of nine patients with alternating hemiplegia of childhood.

作者信息

Tatlı Burak, Aydınlı Nur, Calışkan Mine, Ozmen Meral, Kara Bülent, Yaramış Ahmet, Dilber Cengiz, Yılmaz Kutluhan, Küçükuğurluoğlu Yasemin, Ekici Barış

机构信息

Department of Pediatric Neurology, Istanbul Medical Faculty, Fatih, Istanbul, Turkey.

出版信息

J Paediatr Child Health. 2011 Oct;47(10):734-6. doi: 10.1111/j.1440-1754.2011.02042.x. Epub 2011 Mar 30.

DOI:10.1111/j.1440-1754.2011.02042.x

PMID:21449903

Abstract

AIM

To define clinical features of patients with alternating hemiplegia of childhood.

METHODS

We retrospectively reviewed the clinical presentation and course of the disease in patients diagnosed between January 2003 and December 2008 at the Pediatric Neurology Department of the Istanbul Medical Faculty.

RESULTS

The nine patients had a mean age of 6.6 months (2-15 months) at the onset of symptoms. Paroxysmal eye movements were the early symptom of five patients. All patients had recurrent alternating hemiplegic episodes and relief of symptoms while sleeping. Duration of events varied widely from few minutes to several days and was associated with slowly progressive neurological deterioration. Flunarizine might decrease frequency of events but is not effective to neurological deterioration. Amantadine as an alternative agent is used in add-on therapy, but epileptogenic side effect prevented the evaluation of long-term efficacy.

CONCLUSION

Trials on new agents like amantadine are necessary for more effective control of the disease.

摘要

目的

明确儿童交替性偏瘫患者的临床特征。

方法

我们回顾性分析了2003年1月至2008年12月间在伊斯坦布尔医学院儿科神经科确诊患者的临床表现及病程。

结果

9例患者症状发作时的平均年龄为6.6个月（2至15个月）。阵发性眼球运动是5例患者的早期症状。所有患者均有反复交替性偏瘫发作且在睡眠时症状缓解。发作持续时间差异很大，从几分钟到几天不等，且与缓慢进展的神经功能恶化有关。氟桂利嗪可能会减少发作频率，但对神经功能恶化无效。金刚烷胺作为替代药物用于辅助治疗，但致癫痫副作用妨碍了对其长期疗效的评估。