Paget Simon P, Andresen David N, Kesson Alison M, Egan Jonathan R
Paediatric Intensive Care Unit, The Children's Hospital at Westmead, Westmead, Australia.
J Paediatr Child Health. 2011 Oct;47(10):737-41. doi: 10.1111/j.1440-1754.2011.02043.x. Epub 2011 Mar 30.
To describe the clinical presentation and course of children admitted to the paediatric intensive care unit (PICU) with human metapneumovirus (hMPV) infection, and compare them with children admitted to the PICU with respiratory syncytial virus (RSV) infection.
hMPV was identified by immunofluorescence in 22 children admitted to the PICU over a 16-month period. The medical records of these children were reviewed retrospectively, and their clinical and laboratory data were compared with 66 children admitted to the PICU with positive tests for RSV over the same period.
Children admitted to the PICU with hMPV were significantly older than children with RSV (P= 0.003). Children with hMPV presented more commonly with pneumonia or pneumonitis (29% vs. 16%), and less commonly with bronchiolitis (43% vs. 68%) than RSV (P= 0.13). Invasive ventilation was required in 10 patients (48%) with hMPV, and non-invasive ventilation was required in a further 5 (28%), similar to patients with RSV. Children with hMPV were more likely to have an underlying co-morbidity (P= 0.11).
Children admitted to the PICU with hMPV have a similar disease presentation and severity as children admitted with RSV, including some with extremely severe disease who require additional ventilatory or cardiovascular support. Children with hMPV are likely to be older than those with RSV, and more likely to present with pneumonia and less likely to present with bronchiolitis.
描述入住儿科重症监护病房（PICU）的人偏肺病毒（hMPV）感染患儿的临床表现及病程，并与入住PICU的呼吸道合胞病毒（RSV）感染患儿进行比较。
在16个月期间，通过免疫荧光法在22例入住PICU的患儿中鉴定出hMPV。回顾性分析这些患儿的病历，并将他们的临床和实验室数据与同期66例RSV检测呈阳性且入住PICU的患儿进行比较。
入住PICU的hMPV感染患儿比RSV感染患儿年龄显著更大（P = 0.003）。与RSV感染患儿相比，hMPV感染患儿更常表现为肺炎或肺炎性病变（29%对16%），而较少表现为细支气管炎（43%对68%）（P = 0.13）。10例（48%）hMPV感染患儿需要有创通气，另有5例（28%）需要无创通气，这与RSV感染患儿相似。hMPV感染患儿更可能有基础合并症（P = 0.11）。
入住PICU的hMPV感染患儿与RSV感染患儿有相似的疾病表现和严重程度，包括一些需要额外通气或心血管支持的极重症患儿。hMPV感染患儿可能比RSV感染患儿年龄更大，更易表现为肺炎，而较少表现为细支气管炎。
