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[女性特发性多毛症的病理生理学与治疗。现状]

[Physiopathology and therapy of female idiopathic hirsutism. State of the art].

作者信息

Molinatti G M, Biffignandi P

机构信息

Istituto di Medicina Interna dell'Università degli Studi di Torino.

出版信息

Ann Ital Med Int. 1990 Jan-Mar;5(1):39-47.

PMID:2144992
Abstract

This review aims at focusing current pathogenetic theories on female idiopathic hirsutism. Glandular hormonal synthesis, plasma transport of androgenic hormones, and cutaneous metabolism and utilization of testosterone are discussed in detail. The Authors then propose some therapeutic strategies: antiandrogen drugs are discussed with special reference to cyproterone acetate and spironolactone.

摘要

本综述旨在聚焦当前关于女性特发性多毛症的发病机制理论。详细讨论了腺性激素合成、雄激素的血浆转运以及睾酮的皮肤代谢与利用。作者随后提出了一些治疗策略:特别提及醋酸环丙孕酮和螺内酯,对抗雄激素药物进行了讨论。

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1
[Physiopathology and therapy of female idiopathic hirsutism. State of the art].[女性特发性多毛症的病理生理学与治疗。现状]
Ann Ital Med Int. 1990 Jan-Mar;5(1):39-47.
2
Female hirsutism: pathophysiological considerations and therapeutic implications.女性多毛症:病理生理学考量及治疗意义
Endocr Rev. 1984 Fall;5(4):498-513. doi: 10.1210/edrv-5-4-498.
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Antiandrogens and hirsutism.
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Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in the treatment of hirsutism: a randomised controlled study.氟他胺与螺内酯加乙炔雌二醇/醋酸环丙孕酮治疗多毛症的临床疗效比较:一项随机对照研究。
Adv Ther. 2008 Apr;25(4):321-8. doi: 10.1007/s12325-008-0039-5.
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Comparison of four different treatment regimes in hirsutism related to polycystic ovary syndrome.四种不同治疗方案用于多囊卵巢综合征相关多毛症的比较。
Gynecol Endocrinol. 1996 Aug;10(4):249-55. doi: 10.3109/09513599609012316.
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The treatment of hirsutism: experience with cyproterone acetate and spironolactone.多毛症的治疗:醋酸环丙孕酮和螺内酯的应用经验
Australas J Dermatol. 1985 Apr;26(1):19-24. doi: 10.1111/j.1440-0960.1985.tb01809.x.
7
[Therapy of female hirsutism: current status and new findings].[女性多毛症的治疗:现状与新发现]
Clin Ter. 1983 Mar 31;104(6):447-55.
8
Comparison of sequential cyproterone acetate/estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism.醋酸环丙孕酮/雌激素序贯疗法与螺内酯/口服避孕药治疗多毛症的比较。
J Clin Endocrinol Metab. 1991 May;72(5):1008-13. doi: 10.1210/jcem-72-5-1008.
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Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial.氟他胺与醋酸环丙孕酮治疗多毛症的比较:一项随机对照试验。
Gynecol Endocrinol. 1996 Apr;10(2):119-23. doi: 10.3109/09513599609097901.
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Recurrence rate of hirsutism after 3 different antiandrogen therapies.
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