Outpatient Clinic of the Diabetic Foot, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Int Wound J. 2011 Jun;8(3):297-300. doi: 10.1111/j.1742-481X.2011.00786.x. Epub 2011 Mar 30.
The aim of the present study was to evaluate the efficacy of a new product (Neuropad repair foam(®)) in promoting skin hydration of the foot in type 2 diabetes. Included in this study were 20 type 2 diabetic patients (10 men, mean age 61·40 ± 2·44 years). Patients applied Neuropad repair foam(®) on the plantar aspect of the right foot twice daily. No agent was applied on the left foot. Patients were examined at baseline, after 7 treatment days and after 14 treatment days. Evaluation of skin dryness was performed by means of the Multi Skin test Corneometer MC 900. In the right foot, skin capacitance was 26·55 ± 4·14 arbitrary units (a.u.) at baseline, 28·90 ± 4·53 a.u. after 7 days of treatment and 32·05 ± 4·54 a.u. after 14 days of treatment. There was a significant increase in skin capacitance from baseline to 7 days of treatment (P < 0·001), from baseline to 14 treatment days (P < 0·001), as well as from 7 to 14 days of treatment (P < 0·001). The same significant (P < 0·001) increases were observed both in men and in women. No changes were noted in the left foot. At baseline, there was no difference in skin capacitance between right and left foot (P = 0·186). However, skin capacitance was significantly higher on the right versus left foot, both after 7 days (P < 0·001) and after 14 days of treatment (P < 0·001). In conclusion, results with the new foam appear encouraging in ameliorating skin dryness in the diabetic foot and further investigation is warranted.
本研究旨在评估新型产品（Neuropad repair foam(®)）对改善 2 型糖尿病患者足部皮肤水合作用的疗效。该研究纳入了 20 名 2 型糖尿病患者（10 名男性，平均年龄 61.40 ± 2.44 岁）。患者每天在右脚足底应用 Neuropad repair foam(®)两次。左脚不应用任何药物。患者在基线、治疗 7 天和治疗 14 天后接受检查。通过 Multi Skin test Corneometer MC 900 评估皮肤干燥情况。在右脚，基线时皮肤电容为 26.55 ± 4.14 任意单位（a.u.），治疗 7 天后为 28.90 ± 4.53 a.u.，治疗 14 天后为 32.05 ± 4.54 a.u.。与基线相比，治疗 7 天（P < 0.001）、治疗 14 天（P < 0.001）以及 7 至 14 天治疗期间（P < 0.001），皮肤电容均显著增加。男性和女性均观察到相同的显著增加（P < 0.001）。左脚没有变化。基线时，右脚和左脚的皮肤电容无差异（P = 0.186）。然而，治疗 7 天（P < 0.001）和 14 天（P < 0.001）后，右脚的皮肤电容明显高于左脚。总之，新型泡沫在改善糖尿病足皮肤干燥方面的效果令人鼓舞，需要进一步研究。
