First Department of Propaedeutic Medicine, Laiko General Hospital, Athens University Medical School, Athens, Greece.
Diabetes Care. 2010 May;33(5):1112-4. doi: 10.2337/dc09-2027. Epub 2010 Feb 11.
To examine the association between the moisture status of the skin of the feet with foot ulceration in subjects with diabetes.
A total of 379 subjects with diabetes were examined. Assessment of peripheral neuropathy was based on neuropathy symptom score, neuropathy disability score, vibration perception threshold, and the 10-g monofilament perception. The moisture status of the skin of the feet was assessed using the visual test Neuropad.
Patients with foot ulceration had more severe peripheral neuropathy and more often an abnormal Neuropad response. Multivariate logistic regression analysis demonstrated that the odds of foot ulceration increased with measures of neuropathy but increased also with an abnormal Neuropad response.
An abnormal Neuropad response correlates with foot ulceration in subjects with diabetes. This finding, if confirmed prospectively, suggests that the Neuropad test may be included in the screening tests for the prediction of foot ulceration.
探讨足部皮肤湿度与糖尿病患者足部溃疡之间的关系。
共检查了 379 例糖尿病患者。周围神经病变的评估基于神经病变症状评分、神经病变残疾评分、振动感觉阈值和 10g 单丝感觉。使用视觉测试 Neuropad 评估足部皮肤的湿度状况。
有足部溃疡的患者周围神经病变更严重，且 Neuropad 反应异常的情况更常见。多变量逻辑回归分析表明，足部溃疡的发生几率随神经病变的严重程度增加而增加，但也随 Neuropad 反应异常而增加。
异常的 Neuropad 反应与糖尿病患者的足部溃疡有关。如果前瞻性证实这一发现，表明 Neuropad 测试可能被纳入足部溃疡预测的筛查测试中。
