Department of Urology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Int J Urol. 2011 Jun;18(6):432-8. doi: 10.1111/j.1442-2042.2011.02751.x. Epub 2011 Mar 30.
To investigate the relationship between Eg5 expression and prognosis of patients with non-muscle invasive bladder urothelial carcinoma.
Eg5 expression was examined by immunohistochemistry in non-muscle invasive urothelial carcinoma specimens (grade: G1, 32 cases; G2, 92 cases; and G3, 39 cases. Stage: pTa, 49 cases and pT1, 114 cases). The correlation between clinicopathological characteristics and Eg5 expression was evaluated. The prognostic significance of Eg5 immunoreactivity was analyzed through survival analysis in 163 non-muscle invasive cases that were treated with transurethral resection and adjuvant intravesical instillations.
The expression of Eg5 was significantly associated with tumor grade (P = 0.006), with a trend towards significant association with stage (P = 0.057). The 163 patients with non-muscle invasive tumors were regularly followed with the mean of 32.52 (from 6 to 72) months. Univariate analysis showed Eg5 overexpression exhibited a significant unfavorable influence on intravesical recurrence (P = 0.012) while having only a marginal correlation with disease progression (P = 0.070). Subsequent Cox hazard multivariate analysis showed that both grade (P = 0.045) and Eg5 expression (P = 0.029) were independent predictors for early intravesical recurrence.
Overexpression of Eg5 correlates with poor differentiation of bladder cancer, and it represents an independent prognostic factor in predicting early intravesical recurrence in non-muscle invasive bladder carcinoma patients.
探讨 Eg5 表达与非肌层浸润性膀胱癌患者预后的关系。
采用免疫组织化学方法检测非肌层浸润性尿路上皮癌标本中 Eg5 的表达（分级：G1 级 32 例，G2 级 92 例，G3 级 39 例；分期：pTa 期 49 例，pT1 期 114 例）。评估 Eg5 表达与临床病理特征的相关性。通过对 163 例接受经尿道切除术和辅助膀胱内灌注治疗的非肌层浸润性病例的生存分析，探讨 Eg5 免疫反应的预后意义。
Eg5 的表达与肿瘤分级显著相关（P = 0.006），与分期呈显著相关趋势（P = 0.057）。163 例非肌层浸润性肿瘤患者定期随访，平均随访时间为 32.52 个月（6 至 72 个月）。单因素分析显示，Eg5 过表达对膀胱内复发有显著的不利影响（P = 0.012），而与疾病进展仅有边缘相关性（P = 0.070）。随后的 Cox 风险多因素分析显示，分级（P = 0.045）和 Eg5 表达（P = 0.029）均为早期膀胱内复发的独立预测因素。
Eg5 的过表达与膀胱癌的低分化相关，是预测非肌层浸润性膀胱癌患者早期膀胱内复发的独立预后因素。
