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驱动蛋白家族成员11（KIF11）促进肝癌患者中肝细胞癌的增殖。

KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.

作者信息

Hu Zhan-Dong, Jiang Ying, Sun Hong-Mei, Wang Jing-Wen, Zhai Li-Li, Yin Zhi-Qi, Yan Jun

机构信息

Department of Pathology in Tianjin First Central Hospital, Number 24, Convalescent Road, Nankai, Tianjin 300192, China.

Department of Clinical Laboratory in Tianjin First Central Hospital, Number 24, Convalescent Road, Nankai, Tianjin 300192, China.

出版信息

Biomed Res Int. 2021 Jan 4;2021:2676745. doi: 10.1155/2021/2676745. eCollection 2021.

DOI:10.1155/2021/2676745
PMID:33490265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7801104/
Abstract

BACKGROUND

Hepatocellular carcinoma (HCC) lacks effective treatments and has a poor prognosis. Therefore it is needed to develop more effective drug targets. Kinesin family member 11 (KIF11) has been reported to affect the progression of several cancers, and its high expression associates with the prognosis of patients. However, the relevant mechanisms of KIF11 in HCC progression have not been studied.

METHOD

Through the cancer genome atlas (TCGA) database and immunohistochemical (IHC) staining of patients' specimens, we determined that KIF11 was highly expressed in HCC tissues and associated with prognosis. We established a KIF11 stably depleted hepatoma cell line, through cell-cloning experiments and cell counting kit-8 (CCK-8) assays to detect the effects on proliferation . The role of KIF11 in promoting cell proliferation was verified in mice.

RESULT

The expression of KIF11 was negatively correlated with the overall survival (OS) and disease-free survival (DFS) and positively correlated with tumor size of HCC patients. KIF11 depletion inhibits cell proliferation and tumor growth and . KIF11 can be used as a positive correlation marker for HCC prognosis and served as a potential therapeutic target.

摘要

背景

肝细胞癌（HCC）缺乏有效的治疗方法，预后较差。因此，需要开发更有效的药物靶点。据报道，驱动蛋白家族成员11（KIF11）会影响几种癌症的进展，其高表达与患者的预后相关。然而，KIF11在HCC进展中的相关机制尚未得到研究。

方法

通过癌症基因组图谱（TCGA）数据库和患者标本的免疫组织化学（IHC）染色，我们确定KIF11在HCC组织中高表达且与预后相关。我们建立了一个KIF11稳定缺失的肝癌细胞系，通过细胞克隆实验和细胞计数试剂盒-8（CCK-8）检测其对增殖的影响。在小鼠中验证了KIF11在促进细胞增殖中的作用。

结果

KIF11的表达与HCC患者的总生存期（OS）和无病生存期（DFS）呈负相关，与肿瘤大小呈正相关。KIF11缺失会抑制细胞增殖和肿瘤生长。KIF11可作为HCC预后的正相关标志物，并作为潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/d79aa0d278c4/BMRI2021-2676745.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/8ec2e106eafc/BMRI2021-2676745.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/0602cf467584/BMRI2021-2676745.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/58fe2e8caa53/BMRI2021-2676745.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/b04a570dcddc/BMRI2021-2676745.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/d79aa0d278c4/BMRI2021-2676745.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/8ec2e106eafc/BMRI2021-2676745.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/0602cf467584/BMRI2021-2676745.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/58fe2e8caa53/BMRI2021-2676745.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/b04a570dcddc/BMRI2021-2676745.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/7801104/d79aa0d278c4/BMRI2021-2676745.005.jpg

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2
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3
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Mater Sociomed. 2024;36(4):250-256. doi: 10.5455/msm.2024.36.250-256.
4
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J Transl Med. 2025 Jan 14;23(1):66. doi: 10.1186/s12967-025-06124-y.
5
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6
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