先天性肾病综合征患者使用头孢曲松导致严重免疫性溶血性贫血。
Severe immune haemolytic anaemia due to ceftriaxone in a patient with congenital nephrotic syndrome.
机构信息
Unidade de Nefrologia Pediátrica, Departamento da Criança e da Família, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.
出版信息
Acta Paediatr. 2011 Oct;100(10):e191-3. doi: 10.1111/j.1651-2227.2011.02268.x. Epub 2011 Apr 8.
AIM
To describe the first case of ceftriaxone-related haemolysis in a patient with congenital nephrotic syndrome (CNS).
BACKGROUND
Severe haemolysis caused by an immune reaction to ceftriaxone has mostly been described in patients with underlying haematological or immune dysfunction.
CASE REPORT
The authors present a 20-month-old boy with CNS of the Finnish type with several previous severe infections treated with ceftriaxone, admitted for suspected sepsis. Following ceftriaxone administration he developed shock secondary to an acute haemolytic reaction, with severe anaemia. Hypersensitivity to ceftriaxone was documented through positive agglutination tests.
CONCLUSION
Onset of haemolysis following ceftriaxone administration, particularly in a patient previously exposed to the drug, must raise the suspicion of a possible immune reaction.
目的
描述首例先天性肾病综合征（CNS）患者头孢曲松相关溶血性贫血病例。
背景
头孢曲松引起的严重溶血性贫血主要发生在有潜在血液学或免疫功能障碍的患者中。
病例报告
作者介绍了一例芬兰型 CNS 的 20 个月大男孩，他曾多次因严重感染接受头孢曲松治疗，因疑似败血症入院。在给予头孢曲松后，他发生了因急性溶血性反应引起的休克，伴有严重贫血。通过阳性凝集试验证实对头孢曲松过敏。
结论
头孢曲松给药后出现溶血性贫血，特别是在先前暴露于该药物的患者中，必须引起对可能的免疫反应的怀疑。
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