[头孢曲松诱导的免疫性溶血性贫血和多器官功能衰竭]
[Ceftriaxone-induced immune haemolytic anaemia and multi-organ failure].
作者信息
Mulkens Chantal E, van Lochem Ellen G, Folman Claudia C, van der Spek Ellen, van Leeuwen Henk J
机构信息
Radboudumc, afd. Anesthesiologie, Pijn- en Palliatieve Geneeskunde, Nijmegen.
出版信息
Ned Tijdschr Geneeskd. 2015;159:A8054.
BACKGROUND
Drug-induced immune haemolytic anaemia (DIIHA) is caused by various drugs or their metabolites. Cephalosporins are associated with haemolytic anaemia but multi-organ failure is rarely described.
CASE DESCRIPTION
We report the case of a 57-year-old female who was diagnosed with neuroborreliosis and treated with ceftriaxone. The patient developed severe DIIHA. Massive intravascular haemolysis led to shock and acute renal failure, necessitating mechanical ventilation and dialysis. Treatment with ceftriaxone was discontinued and glucocorticoids were prescribed. The patient recovered slowly but fully.
CONCLUSION
Ceftriaxone-induced immune haemolytic anaemia is a rare but potentially fatal condition.
背景
药物性免疫性溶血性贫血（DIIHA）由各种药物或其代谢产物引起。头孢菌素与溶血性贫血有关，但多器官功能衰竭很少被描述。
病例描述
我们报告一例57岁女性，被诊断为神经莱姆病并接受头孢曲松治疗。患者发生了严重的DIIHA。大量血管内溶血导致休克和急性肾衰竭，需要机械通气和透析。停用头孢曲松并给予糖皮质激素治疗。患者恢复缓慢但完全康复。
结论
头孢曲松诱导的免疫性溶血性贫血是一种罕见但可能致命的疾病。
Zotero 插件