Choussy O, Bertrand M, François A, Blot E, Hamidou H, Dehesdin D
Department of Head and Neck Surgery, Rouen University Hospital, Rouen, France.
J Laryngol Otol. 2011 Jun;125(6):608-13. doi: 10.1017/S0022215111000491. Epub 2011 Mar 30.
To evaluate the clinical course and pathological characteristics of basaloid head and neck squamous cell carcinoma.
Retrospective study of 18 cases of basaloid head and neck squamous cell carcinoma. Epidemiological, clinical and histological data were analysed and the Kaplan-Meier test used to estimate survival rates.
The majority of lesions were at an advanced stage. These lesions were primarily localised in the larynx, hypopharynx and oropharynx. Routine pre-therapeutic assessment of squamous cell carcinoma was performed. Pathological diagnosis was difficult, although immunostaining was extremely useful. Positive staining for KL1, MNF 116 and 34βE12 and negative immunostaining for chromogranin and synaptophysin were also important factors in obtaining a definitive diagnosis. In the majority of cases, treatment involved surgery and radiotherapy. The five-year survival rate was 5 per cent.
Basaloid squamous cell carcinoma is an uncommon head and neck lesion, with a challenging histological diagnosis. These lesions must be carefully monitored due to their aggressive course, and require multimodality treatment.
评估基底样头颈部鳞状细胞癌的临床病程及病理特征。
对18例基底样头颈部鳞状细胞癌进行回顾性研究。分析流行病学、临床及组织学数据，并采用Kaplan-Meier检验来估计生存率。
大多数病变处于晚期。这些病变主要位于喉、下咽和口咽。对鳞状细胞癌进行了常规的治疗前评估。病理诊断困难，尽管免疫染色极为有用。KL1、MNF 116和34βE12阳性染色以及嗜铬粒蛋白和突触素免疫染色阴性也是获得明确诊断的重要因素。在大多数病例中，治疗包括手术和放疗。五年生存率为5%。
基底样鳞状细胞癌是一种不常见的头颈部病变，组织学诊断具有挑战性。由于其侵袭性病程，这些病变必须仔细监测，并需要多模式治疗。
