Kumari Karuna, Haragannavar Vanishree C, Kumar K Vineeth, Prasad Kavitha, Nambiar Shwetha
Postgraduate Student, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Assistant Professor, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
J Clin Diagn Res. 2017 Mar;11(3):ZD16-ZD18. doi: 10.7860/JCDR/2017/24308.9539. Epub 2017 Mar 1.
Basaloid Squamous Cell Carcinoma (BSCC) is a rare entity with its histopathological distinction from conventional squamous cell carcinoma. It is frequently considered a high-grade carcinoma with poor prognosis because of higher rate of distant metastases. Here by, we are reporting a case of 39-year-old male with an ulcer on the left lateral border of the tongue since a month. Histopathological examination of incisional biopsy revealed basaloid tumour cell islands accompanied by component of well differentiated squamous cell carcinoma. To reconfirm this incidental finding immunohistochemistry was carried out for Proliferative Cell Nuclear Antigen (PCNA) and pancytokeratin (AE1/AE3) which was positive to conclude diagnosis of BSCC. Further p16 staining was done to rule out Human Papilloma Virus (HPV) infection.
基底样鳞状细胞癌（BSCC）是一种罕见的疾病，在组织病理学上与传统鳞状细胞癌有所不同。由于远处转移率较高，它常被认为是一种预后较差的高级别癌。在此，我们报告一例39岁男性，其左侧舌缘出现溃疡已有一个月。切开活检的组织病理学检查显示基底样肿瘤细胞岛伴有高分化鳞状细胞癌成分。为再次确认这一偶然发现，对增殖细胞核抗原（PCNA）和全细胞角蛋白（AE1/AE3）进行了免疫组织化学检测，结果均为阳性，从而确诊为BSCC。进一步进行p16染色以排除人乳头瘤病毒（HPV）感染。
