Department of Intensive Care Medicine, Royal Adelaide Hospital, South Australia, Australia.
Gut. 2011 Oct;60(10):1336-43. doi: 10.1136/gut.2010.227934. Epub 2011 Mar 29.
It is assumed that delayed gastric emptying (GE) occurs frequently in critical illness; however, the prevalence of slow GE has not previously been assessed using scintigraphy. Furthermore, breath tests could potentially provide a convenient method of quantifying GE, but have not been validated in this setting. The aims of this study were to (i) determine the prevalence of delayed GE in unselected, critically ill patients and (ii) evaluate the relationships between GE as measured by scintigraphy and carbon breath test.
Prospective observational study.
Mixed medical/surgical intensive care unit.
25 unselected, mechanically ventilated patients (age 66 years (49-72); and 14 healthy subjects (age 62 years (19-84)).
GE was measured using scintigraphy and (14)C-breath test. A test meal of 100 ml Ensure (standard liquid feed) labelled with (14)C octanoic acid and (99m)Technetium sulphur colloid was placed in the stomach via a nasogastric tube.
Gastric 'meal' retention (scintigraphy) at 60, 120, 180 and 240 min, breath test t(50) (BTt(50)), and GE coefficient were determined.
Of the 24 patients with scintigraphic data, GE was delayed at 120 min in 12 (50%). Breath tests correlated well with scintigraphy in both patients and healthy subjects (% retention at 120 min vs BTt(50); r(2)=0.57 healthy; r(2)=0.56 patients; p≤0.002 for both).
GE of liquid nutrient is delayed in approximately 50% of critically ill patients. Breath tests correlate well with scintigraphy and are a valid method of GE measurement in this group.
据推测，在危重病中经常会出现胃排空延迟（GE）；然而，以前尚未使用闪烁扫描法来评估缓慢 GE 的患病率。此外，呼吸测试可能提供一种方便的定量 GE 的方法，但尚未在这种情况下得到验证。本研究的目的是：（i）确定未选择的危重病患者中 GE 延迟的患病率；（ii）评估闪烁扫描法和碳呼吸测试测量的 GE 之间的关系。
前瞻性观察研究。
混合内科/外科重症监护病房。
25 名未选择的机械通气患者（年龄 66 岁（49-72 岁）；和 14 名健康受试者（年龄 62 岁（19-84 岁））。
使用闪烁扫描法和（14）C-呼吸测试测量 GE。通过鼻胃管将 100ml Ensure（标准液体饲料）放入胃中，该饲料用（14）C 辛酸和（99m）锝硫胶体标记。
胃“餐”在 60、120、180 和 240 分钟时的保留率（闪烁扫描法），呼吸测试 t（50）（BTt（50））和 GE 系数。
在具有闪烁扫描数据的 24 名患者中，12 名（50%）患者在 120 分钟时出现 GE 延迟。呼吸测试与患者和健康受试者的闪烁扫描法相关性良好（120 分钟时的保留率与 BTt（50）；r（2）=0.57 健康；r（2）=0.56 患者；两者均 p≤0.002）。
液体营养物的 GE 在大约 50%的危重病患者中延迟。呼吸测试与闪烁扫描法相关性良好，是该组 GE 测量的有效方法。
