Taty-Taty R, Saliou P, Yala F, Couroucé A M, Arthaud M L, Nerelli B, Biendo M, Wassoumbou E
Laboratoire de l'Hôpital Central des Armées, Brazzaville, Congo.
Bull Soc Pathol Exot. 1990;83(2):155-8.
The aim was to study the immunogenicity of a plasma-derived vaccine against Hepatitis B Virus administrated in 3 injections at month 0-1-6. Only subjects without HBs Ag and anti-HBc were vaccinated. The seroconversion rates were 79.21% at day 90, 77.50% at day 180 and 87.21% at day 210. At the same dates, the mean geometric titres of anti-HBs (mUI/ml) were respectively 115.01, 100.48 and 772.78. In all subjects, the vaccine was very well tolerated. This 3 injections protocol of vaccination instead of the classical 4 injections protocol significantly reduces the cost of vaccination and may enlarge its application.
目的是研究一种乙肝病毒血浆源性疫苗的免疫原性，该疫苗在第0、1、6个月分3次注射。仅对无乙肝表面抗原（HBs Ag）和乙肝核心抗体（anti-HBc）的受试者进行疫苗接种。第90天时血清转化率为79.21%，第180天时为77.50%，第210天时为87.21%。在相同时间，抗-HBs的平均几何滴度（mUI/ml）分别为115.01、100.48和772.78。在所有受试者中，该疫苗耐受性良好。这种3针接种方案而非传统的4针接种方案显著降低了疫苗接种成本，并可能扩大其应用范围。
