Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30030, USA.
J Clin Microbiol. 2011 Jun;49(6):2350-3. doi: 10.1128/JCM.02547-10. Epub 2011 Mar 30.
Fusarium is a ubiquitous mold that can cause superficial infections such as keratitis and onychomycosis in immunocompetent humans; however, infections in immunocompromised hosts can be fatal. We report an unusual case of epidural abscess and vertebral osteomyelitis in a patient with an autoimmune disorder who was on long-term glucocorticoids. Multilocus DNA sequence-based typing revealed that the infection was caused by a novel three-locus haplotype of Fusarium falciforme designated FSSC 3+4qqq.
镰刀菌是一种无处不在的霉菌,可导致免疫功能正常的人群发生角膜炎和甲真菌病等浅表感染;然而,免疫功能低下宿主的感染可能是致命的。我们报告了一例患有自身免疫性疾病并长期使用糖皮质激素的患者发生硬膜外脓肿和脊椎骨髓炎的不常见病例。多位点 DNA 序列基于分型显示,感染是由一种新型镰刀菌 FSSC 3+4qqq 的三基因座单倍型引起的。