Okura Yuka, Kawamura Nobuaki, Okano Motohiko, Toita Nariaki, Takezaki Shunichiro, Yamada Masafumi, Kobayashi Ichiro, Ariga Tadashi
Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Pediatr Int. 2015;57(1):e4-6. doi: 10.1111/ped.12458.
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease characterized by recurrent life-threatening bacterial and fungal infections with granuloma formation. Species of the genus Fusarium are opportunistic environmental microorganisms that are rarely pathogenic in humans. We report here the first case of X-linked CGD complicated with epidural abscess caused by Fusarium falciforme infection. The abscesses extended along the dura mater for >7 years and finally resulted in fatal meningitis and cervical myelitis. Early intervention with hematopoietic stem cell transplantation should be considered, especially in patients with severe CGD, before the development of serious infectious complication.
慢性肉芽肿病（CGD）是一种原发性免疫缺陷病，其特征为反复发生危及生命的细菌和真菌感染并形成肉芽肿。镰刀菌属是机会性环境微生物，在人类中很少致病。我们在此报告首例X连锁慢性肉芽肿病合并由镰状镰刀菌感染引起的硬膜外脓肿。脓肿沿硬脑膜扩展超过7年，最终导致致命的脑膜炎和颈髓炎。应考虑早期进行造血干细胞移植干预，尤其是对于重症慢性肉芽肿病患者，在严重感染并发症发生之前。
