对乙酰氨基酚诱发的固定型药疹伴免疫荧光检查阳性结果。

Paracetamol-induced fixed drug eruption with positive immunofluorescence findings.

作者信息

Duhra P, Porter D I

机构信息

Skin Department, St. Marks Annexe, Coventry, UK.

出版信息

Clin Exp Dermatol. 1990 Jul;15(4):293-5. doi: 10.1111/j.1365-2230.1990.tb02093.x.

DOI:10.1111/j.1365-2230.1990.tb02093.x

PMID:2145100

Abstract

A 93-year-old woman with an 8-year history of episodes of fixed drug eruption due to paracetamol is described. The rash was characterized by bullae, crusted lesions, hyperpigmented and erythematous patches as well as lesions resembling toxic epidermal necrolysis. Direct immunofluorescence revealed deposition of IgG and C3 in the epidermal intercellular cement substance of lesional skin only; the pathogenetic significance of this finding is discussed.

摘要

本文描述了一位93岁女性，有因对乙酰氨基酚引发固定性药疹发作8年的病史。皮疹的特征为水疱、结痂性皮损、色素沉着和红斑性斑块，以及类似中毒性表皮坏死松解症的皮损。直接免疫荧光显示仅在皮损皮肤的表皮细胞间黏合质中有IgG和C3沉积；对这一发现的致病意义进行了讨论。