De Coninck A L, Van Strubarq A S, Pipeleers-Marichal M A, Huyghens L P, Suys E T, Roseeuw D I
Department of Dermatology, Academic Hospital, Vrije Universiteit Brussel, Belgium.
Dermatology. 1996;193(4):338-41. doi: 10.1159/000246286.
We report on a 28-year-old Bangladesh man with acute generalized exanthematous pustulosis, induced by paracetamol. The patient presented with an erythematous and pustular eruption after taking 1 tablet of paracetamol for a sore throat. After intravenous administration of propacetamol hydrochloride (which is a prodrug of paracetamol), the rash became worse, showing a toxic epidermal necrolysis-like appearance and the patient suffered from severe hemodynamic disturbances. After discontinuation of propacetamol hydrochloride, the eruption cleared within 2 days. Prick testing performed in the patient revealed a positive reaction for propacetamol hydrochloride.
我们报告了一名28岁的孟加拉国男子，他因对乙酰氨基酚诱发急性泛发性脓疱性皮病。该患者因喉咙痛服用1片对乙酰氨基酚后出现红斑和脓疱疹。静脉注射盐酸丙帕他莫（对乙酰氨基酚的前体药物）后，皮疹加重，呈现中毒性表皮坏死松解样外观，患者出现严重的血流动力学紊乱。停用盐酸丙帕他莫后，皮疹在2天内消退。对该患者进行的点刺试验显示对盐酸丙帕他莫呈阳性反应。
