Faculty of Science, Palacký University in Olomouc, Slechtitelů 11, 783 71, Olomouc-Holice, Czech Republic.
J Biosci. 2011 Mar;36(1):189-200. doi: 10.1007/s12038-011-9020-6.
The Potyviridae family, named after its type member, Potato virus Y (PVY), is the largest of the 65 plant virus groups and families currently recognized. The coding region for P1 peptidase is located at the very beginning of the viral genome of the family Potyviridae. Until recently P1 was thought of as serine peptidase with RNA-binding activity and with possible influence in cell-to-cell viral spreading. This N-terminal protein, among all of the potyviruses, is the most divergent protein: varying in length and in its amino acid sequence. Nevertheless, P1 peptidase in many ways is still a mysterious viral protein. In this review, we would like to offer a comprehensive overview, discussing the proteomic, biochemical and phylogenetic views of the P1 protein.
Potyviridae 科是以其模式成员马铃薯 Y 病毒（PVY）命名的，是目前已识别的 65 个植物病毒组和科中最大的一个。P1 蛋白酶的编码区位于该科病毒基因组的最前端。直到最近，P1 一直被认为是一种具有 RNA 结合活性并可能影响细胞间病毒传播的丝氨酸蛋白酶。在所有的马铃薯 Y 属病毒中，这种 N 端蛋白是最具差异的蛋白：长度和氨基酸序列都有所不同。然而，P1 蛋白酶在很多方面仍然是一种神秘的病毒蛋白。在这篇综述中，我们将全面讨论 P1 蛋白的蛋白质组学、生化和系统发育观点。
