Resistant systemic hypertension.

Resistant hypertension is defined as failure to achieve goal blood pressure (BP) when a patient adheres to the maximum tolerated doses of three antihypertensive drugs including a diuretic. Although the exact prevalence of resistant hypertension is currently unknown, indirect evidence from population studies and clinical trials suggests that it is a relatively common clinical problem. Exclusion of preparations that contribute to true BP treatment resistance, such as NSAIDs and certain herbs, is also important. In Syria and other middle-eastern countries, licorice juice ingestion is considered as a distinct reason for resistant hypertension.