根据血清抗缪勒管激素浓度预测绝经年龄。

Predicting age at menopause from serum antimüllerian hormone concentration.

机构信息

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Menopause. 2011 Jul;18(7):766-70. doi: 10.1097/gme.0b013e318205e2ac.

DOI:10.1097/gme.0b013e318205e2ac

PMID:21451424

Abstract

OBJECTIVE

We aimed to estimate age at menopause using serum antimüllerian hormone (AMH) concentration.

METHODS

We randomly selected 266 study participants from a pool of 1,265 eligible women in the Tehran Lipid and Glucose Study cohort. We measured AMH levels three times at about 3-year intervals. There were 63 occurrences of menopause in our participants over an average of 6-year follow-up. We built an accelerated failure time model using serum AMH level at the start of follow-up to estimate age at menopause. The goodness of fit for the model was tested using Cox-Snell residuals and the Bland-Altman plot.

RESULTS

We estimated ages at menopause for different levels of serum AMH concentration among women aged 20 to 49 years. For those who reached menopause, serum AMH concentrations about 6 years before the event provided fairly accurate estimates of the age at menopause. The Bland-Altman plot showed an acceptable agreement between predicted and observed values.

CONCLUSIONS

Serum AMH concentrations can reasonably forecast the age at menopause for individual women.

摘要

目的

我们旨在通过血清抗缪勒管激素（AMH）浓度来估算绝经年龄。

方法

我们从德黑兰血脂和血糖研究队列中随机选择了 266 名符合条件的女性中的 266 名研究参与者。我们在大约 3 年的时间间隔内测量了 AMH 水平三次。在平均 6 年的随访中，我们的参与者中有 63 例发生了绝经。我们使用随访开始时的血清 AMH 水平建立了加速失效时间模型，以估算绝经年龄。通过 Cox-Snell 残差和 Bland-Altman 图测试模型的拟合优度。