情感障碍中的拷贝数变异及荟萃分析。

Copy number variations in affective disorders and meta-analysis.

作者信息

Olsen Line, Hansen Thomas, Djurovic Srdjan, Haastrup Eva, Albrecthsen Anders, Hoeffding Louise K E, Secher Anna, Gustafsson Omar, Jakobsen Klaus D, Nielsen Finn C, Ullum Henrik, Morken Gunnar, Agartz Ingrid, Melle Ingrid, Gether Ulrik, Andreassen Ole A, Werge Thomas

机构信息

Institute for Biological Psychiatry, Mental Health Centre Sct. Hans, Roskilde, Norway.

出版信息

Psychiatr Genet. 2011 Dec;21(6):319-22. doi: 10.1097/YPG.0b013e3283463deb.

DOI:10.1097/YPG.0b013e3283463deb

PMID:21451435

Abstract

In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.

摘要

在最近的两项研究中，发现10种拷贝数变异（CNV）在一个阿米什家族中患有情感障碍的患者中，或者在威康信托病例对照协会研究中，出现的频率过高。在此，我们通过对来自丹麦、挪威和冰岛的三个病例对照样本进行联合分析，来研究这些变异是否与情感障碍有关。我们对10个基因组位点的CNV进行了分析，共纳入1897例患者（n = 1223例单相情感障碍患者和n = 463例双相情感障碍患者）和11231名对照，但我们发现这些CNV与情感障碍之间不存在联合关联。