Furlong R A, Ho L, Rubinsztein J S, Walsh C, Paykel E S, Rubinsztein D C
Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Am J Med Genet. 1998 May 8;81(3):245-7.
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylase gene. A total of 118 bipolar, 125 unipolar, and 437 control subjects were used in the study (1:3.7 bipolar:control, 1:3.5 unipolar:control). There were no significant differences in TPH allele or genotype frequencies between the affective disorder and control groups. In addition, bipolar and/or unipolar subjects with or without a history of suicide attempts were compared for the TPH polymorphism. No significant differences were found between suicidal and non-suicidal groups in major affective disorder, in contrast to a previous study suggesting an association of this polymorphism with a history of suicide attempts among alcoholic violent offenders.
色氨酸羟化酶（TPH）是5-羟色胺（5-HT）合成过程中的限速酶。通过利用色氨酸羟化酶基因第7内含子中的Bfa I限制性酶切位点多态性，对I型双相情感障碍或单相重度情感障碍进行了关联研究。该研究共纳入了118例双相情感障碍患者、125例单相情感障碍患者以及437名对照者（双相情感障碍与对照者的比例为1:3.7，单相情感障碍与对照者的比例为1:3.5）。情感障碍组与对照组之间的TPH等位基因或基因型频率无显著差异。此外，还对有或无自杀未遂史的双相情感障碍和/或单相情感障碍患者的TPH多态性进行了比较。与之前一项研究表明该多态性与酒精性暴力犯罪者的自杀未遂史有关相反，在重度情感障碍中，自杀组与非自杀组之间未发现显著差异。
