Department of Cellular and Molecular Physiology, Combined Programs in Biological and Biomedical Sciences, Section of Comparative Medicine, Integrative Cell Signaling, and Neurobiology of Metabolism (ICSNM), Yale University School of Medicine, New Haven, Connecticut, USA.
Yale J Biol Med. 2011 Mar;84(1):1-7.
The 2010 Lasker Award for basic medical research was shared by Douglas Coleman and Jeffery Friedman for their discovery of leptin, a breakthrough that revealed insight into the genetic basis of obesity. This mini-review aims to review landmark studies on the physiologic system of body weight control. The basic research on the leptin system has broad implications for the genetic control of body weight, thus contributing to solve the global obesity crisis.
2010 年拉斯克基础医学研究奖授予道格拉斯·科尔曼（Douglas Coleman）和杰弗里·弗里德曼（Jeffrey Friedman），以表彰他们发现瘦素（leptin）。这一突破性发现揭示了肥胖症遗传基础方面的新见解。本文旨在回顾体重控制生理系统的里程碑式研究。瘦素系统的基础研究对体重的遗传控制具有广泛的影响，有助于解决全球肥胖危机。
