用于癌症诊断和治疗的可逃逸内涵体的磁性聚（氨基酸）纳米粒子。
Endosome-escapable magnetic poly(amino acid) nanoparticles for cancer diagnosis and therapy.
机构信息
Department of Chemical and Biomolecular Engineering (BK21 Graduate Program), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
出版信息
Chem Commun (Camb). 2011 May 14;47(18):5322-4. doi: 10.1039/c1cc10371g. Epub 2011 Mar 30.
PMID:21451847
Abstract
Endosome-escapable poly(amino acid) nanoparticles composed of iron oxide nanocrystals and anticancer drugs were prepared and demonstrated high T(2) relaxivity coefficients and higher efficacy attributed to the endosomolytic ability of the conjugated histidine moiety.
摘要
制备了由氧化铁纳米晶体和抗癌药物组成的可逃避内涵体的聚（氨基酸）纳米粒子，并证明其具有高 T2 弛豫率系数和更高的功效，这归因于共轭组氨酸部分的内涵体溶酶体能力。
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