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一锅法合成用于动脉粥样硬化靶向磁共振成像的磁性纳米团簇

One-pot synthesis of magnetic nanoclusters enabling atherosclerosis-targeted magnetic resonance imaging.

作者信息

Kukreja Aastha, Lim Eun-Kyung, Kang Byunghoon, Choi Yuna, Lee Taeksu, Suh Jin-Suck, Huh Yong-Min, Haam Seungjoo

机构信息

Department of Chemical and Biomolecular Engineering, College of Engineering Yonsei University, Seoul, Republic of Korea.

Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea ; YUHS-KRIBB Medical Convergence Research Institute, Seoul, Republic of Korea ; BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

出版信息

Int J Nanomedicine. 2014 May 21;9:2489-98. doi: 10.2147/IJN.S55525. eCollection 2014.

DOI:10.2147/IJN.S55525
PMID:24904209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4039422/
Abstract

In this study, dextran-encrusted magnetic nanoclusters (DMNCs) were synthesized using a one-pot solution phase method for detection of atherosclerosis by magnetic resonance imaging. Pyrenyl dextran was used as a surfactant because of its electron-stabilizing effect and its amphiphilic nature, rendering the DMNCs stable and water-dispersible. The DMNCs were 65.6±4.3 nm, had a narrow size distribution, and were superparamagnetic with a high magnetization value of 60.1 emu/g. Further, they showed biocompatibility and high cellular uptake efficiency, as indicated by a strong interaction between dextran and macrophages. In vivo magnetic resonance imaging demonstrated the ability of DMNCs to act as an efficient magnetic resonance imaging contrast agent capable of targeted detection of atherosclerosis. In view of these findings, it is concluded that DMNCs can be used as magnetic resonance imaging contrast agents to detect inflammatory disease.

摘要

在本研究中，采用一锅溶液相法合成了葡聚糖包裹的磁性纳米团簇（DMNCs），用于通过磁共振成像检测动脉粥样硬化。芘基葡聚糖因其电子稳定作用和两亲性质而被用作表面活性剂，使DMNCs稳定且可水分散。DMNCs的粒径为65.6±4.3nm，粒径分布窄，具有超顺磁性，高磁化值为60.1emu/g。此外，如葡聚糖与巨噬细胞之间的强相互作用所示，它们表现出生物相容性和高细胞摄取效率。体内磁共振成像证明DMNCs能够作为一种有效的磁共振成像造影剂，能够靶向检测动脉粥样硬化。鉴于这些发现，得出结论：DMNCs可作为磁共振成像造影剂用于检测炎症性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/7514cebb40dd/ijn-9-2489Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/3f122b1bbb21/ijn-9-2489Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/94cd823e7849/ijn-9-2489Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/161d6a9b870f/ijn-9-2489Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/7ec3289c87f8/ijn-9-2489Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/d8f686ce978e/ijn-9-2489Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/61b376c38da8/ijn-9-2489Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/6185d8cfdf49/ijn-9-2489Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/36bf09d8ccc1/ijn-9-2489Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/7514cebb40dd/ijn-9-2489Fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/3f122b1bbb21/ijn-9-2489Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/94cd823e7849/ijn-9-2489Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/161d6a9b870f/ijn-9-2489Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/7ec3289c87f8/ijn-9-2489Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/d8f686ce978e/ijn-9-2489Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/61b376c38da8/ijn-9-2489Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/6185d8cfdf49/ijn-9-2489Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/36bf09d8ccc1/ijn-9-2489Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc93/4039422/7514cebb40dd/ijn-9-2489Fig9.jpg

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